Joan Sala

Nom:
Joan Sala
Firma: Joan Sala
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Responsable del Grup

Validation of a population coronary disease predictive system: the CASSANDRA model.

Validation of a population coronary disease predictive system: the CASSANDRA model.

BACKGROUND: The use of validated multivariate cardiovascular predictive models in a population setting is of interest for public health policy makers. We aimed to validate the estimations of the CASSANDRA model (coronary heart disease (CHD) incidence and CHD risk distribution), considering the population changes in age, sex and CHD risk factors prevalence in a 10-year period. METHODS: We compared the projected CHD incidence estimated with CASSANDRA with that observed in the Girona Heart Registry (REGICOR) for 1995-2004 and 2000-2009 in the population of Girona (Spain) aged 35-74 years.

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Socioeconomic status and risk of acute myocardial infarction. Population-based case-control study.

Socioeconomic status and risk of acute myocardial infarction. Population-based case-control study.

INTRODUCTION AND OBJECTIVES: Socioeconomic status is associated with cardiovascular mortality. The aims of this study were to investigate the association between socioeconomic status and its various indicators and the risk of acute myocardial infarction (AMI), and to determine whether any association found is independent of the presence of cardiovascular risk factors (CVRFs). METHODS: Study cases were matched with controls by age, sex and year of recruitment. Cases were recruited from a hospital register and controls from cross-sectional studies of the general population.

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Transforming growth factor beta 1 as a biomarker of diabetic peripheral neuropathy: cross-sectional study.

Transforming growth factor beta 1 as a biomarker of diabetic peripheral neuropathy: cross-sectional study.

BACKGROUND: Simple and efficient screening methods are lacking for diabetic peripheral neuropathy (DPN), the most common and most difficult to treat of the long-term diabetic complications. Increased levels of transforming growth factor beta 1 (TGFbeta1) in type 2 diabetic patients (T2DM) plays an immunomodulatory role in diabetic nephropathy and, possibly, in atherosclerotic evolution. Since preliminary interrelationships between experimental DPN and TGFbeta1 have been observed, we sought to assess whether TGFbeta1 could be a biomarker molecule for human DPN.

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