Josep Daunis-I-Estadella

Nom:
Josep Daunis
Firma: Josep Daunis-I-Estadella
Posició:
Col·laboradors

Brain Iron Overload, Insulin Resistance and Cognitive Performance in Obese Subjects: A Preliminary MRI Case-Control Study

Brain Iron Overload, Insulin Resistance and Cognitive Performance in Obese Subjects: A Preliminary MRI Case-Control Study

OBJECTIUS: The linkage among the tissue iron stores, insulin resistance (IR), and cognition remains unclear in the obese population. We aimed to identify the factors that contribute to increased hepatic iron concentration (HIC) and brain iron overload (BIO), as evaluated by MRI, and to evaluate their impact on cognitive performance in obese and nonobese subjects.

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KCNK17 genetic variants in ischemic stroke.

KCNK17 genetic variants in ischemic stroke.

BACKGROUND: Genetic factors contribute to the development of ischemic stroke (IS). In order to identify susceptibility variants, we analyzed single nucleotide polymorphisms (SNPs) that had been previously linked to stroke in a genome-wide association study. METHODS: We analyzed 12 SNPs in a White population comprising IS patients and healthy controls. The analysis was adjusted for confounding variables and stratified by stroke etiology. Functional studies were then performed to elucidate the role of these variants in IS.

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IL1B and VWF variants are associated with fibrinolytic early recanalization in patients with ischemic stroke.

IL1B and VWF variants are associated with fibrinolytic early recanalization in patients with ischemic stroke.

BACKGROUND AND PURPOSE: There is a great interindividual variability among patients with acute ischemic stroke regarding the response to intravenous tissue-type plasminogen activator treatment. The aim of this study was to identify genetic variants associated with recanalization, and thus treatment efficacy, after tissue-type plasminogen activator administration.

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