Ribó M, Bosch M, Torrent G, Benito A, Beaumelle B. and Vilanova M. Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation process of onconase. Eur J Biochem. (2004) 271(6), 1163-71.
Bosch M, Benito A, Ribó M, Puig T, Beaumelle B, and Vilanova M. A nuclear localization sequence endows human pancreatic ribonuclease with cytotoxic activity.Biochemistry (2004) 43(8), 2167-77.
Benito, A., Ribó, M. and Vilanova, M.On the track of antitumour ribonucleases Molecular BioSystems (2005) 1, 294-302.
Ribó, M., Font, J., Benito, A., Torrent, J., Lange, R. & Vilanova, M. Pressure as a tool to study protein-unfolding/refolding processes: the case of ribonuclease A. Biochim. Biophys. Acta (2006) 1764, 461-469.
Torrent, J., Font, J., Herberhold, H., Marchal, S., Ribó, M., Ruan, K., Winter, R., Vilanova, M. & Lange, R. The use of pressure-jump relaxation kinetics to study protein folding landscapes. Biochim. Biophys. Acta (2006) 1764, 489-496
Font, J., Benito, A., Torrent, J., Lange, R., Ribó, M., & Vilanova, M. Pessure- and temperature-induced unfolding studies: Thermodynamics of core hydrophobicity and packing of ribonuclease A.Biol. Chem. (2006) 387, 285- 296
López-Alonso, J. P., Bruix, M., Font, J., Ribó, M., Vilanova, M., Rico, M., Gotte, G., Libonati, M., González, C. & Laurents, D. V. Formation, Structure and dissociation of the ribonuclease A three-dimensional domain-swapped dimer. J. Biol. Chem. (2006) 281, 9400-9406
Rodríguez, M., Benito, A., Ribó, M. & Vilanova, M. Characterizaction of the dimerization process of a domain-swapped dimeric variant of human pancreatic ribonuclease.FEBS J. (2006) 273, 1166 - 1176
Font, J.,Benito, A., Lange, R., Ribó, M. & Vilanova, M. The contribution of the residues from the main hydrophobic core of ribonuclease A to its pressure-folding transition state. Protein Science (2006) 15, 1000-1009
Rodríguez, M., Benito, A., Tubert, P., Castro, J., Ribó, M., Beaumelle, B. & Vilanova, M. A cytotoxic ribonuclease variant with a discontinuous nuclear localization signal constituted by basic residues scattered over three areas of the molecule. J. Molecular Biology (2006) 360, 548-552
Font, J.,Torrent, Ribó, M., Laurents, D.V., Vilanova, M. & Lange, R. Pressure-jump induced kinetics reveals a hydration dependent folding/unfolding mechanism of ribonuclease A. Biophys. J. (2006) 91, 2264-2274.
Nikolovski, Z.; Buzón, V.; Ribó, M.; Moussaoui, M.; Vilanova, M.; Cuchillo, C.M.; Cladera, J.; Nogués, M.V. Thermal unfolding of eosinophil cationic protein/ribonuclease 3: a nonreversible process. Protein Science (2006) 15, 2816 – 2827.
Rodríguez, M., Torrent, G., Bosch, M., Rayne, F., Dubremetz, J-F, Ribó, M., Benito, A. , Vilanova, M. & Beaumelle,B. Intracellular pathway of onconase that enables its delivery to the cytosol. J. Cell Sci. (2007) 120, 1405-1411.
Bruix, M., Ribó, M., Benito, A., Laurents, D.V., Rico, M. & Vilanova, M. Destabilizing mutations alter the hydrogen exchange mechanism of RNase A. Biophys. J. (2008) 94 , 2297-2305.
Torrent J., Marchal, S., Ribó, M., Vilanova, M., Georges, C., Dupont, Y. & Lange R. Distinct unfolding and refolding pathways of ribonuclease A revealed by heating and cooling temperature jumps. Biophys. J. (2008) 94, 4056- 4065.
Rodríguez, M., Moussaoui, M, Benito, A., Cuchillo, C.M., Nogués, M.V. & Vilanova, M, Título: Human pancreatic ribonuclease presents higher endonucleolytic activity than ribonuclease A. Arch. Biochem. Biophys. (2008) 471, 191-197.
Torrent, G, Benito, A., Castro, J., Ribó, M. & Vilanova, M. Contribution of the C30/C75 didulfide bond to the biological properties of onconase. Biol. Chem. (2008) DOI: 10.1515/BC.2008.XXX), en premsa.
The structural determinants that lead to the formation of particular oligomeric structures in the pancreatic-type ribonuclease family. Curr. Peptide and Protein Sci. (2008), 9, en premsa.
Benito, A., Vilanova, M. & Ribó, M. Intracellualr routing of cytotoxic pancreatic-type ribonucleases.Curr. Pharmaceutical Biotechnology (2008) 9, en premsa.
Composición del grupo
Dirección del grupo: Dra. Maria Vilanova, Catedràtica d’Universitat de Bioquímica i Biologia Molecular (IP). Dr. Marc Ribó, Professor Titular d’Universitat de Bioquímica i Biologia Molecular. Dr. Antoni Benito, Professor Titular d’Universitat de Bioquímica i Biologia Molecular. Tel. +34972418173 / 8388 Fax +34972418150
Correu electrònic:
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Miembros del grupo:
Profesores asociados: Gerard Torrent Pere Tubert Becarios: Jessica Castro Mariona Callís Roger Vilà Anna Vert
Ubicación de laboratorio Laboratori d’enginyeria de Proteïnes Dept. De Biologia Fac. De Ciències Campus de Montilivi s/n 17071 Girona
