Neurodegeneration and neuroinflamation

English

Multiple Sclerosis (MS) currently lacks a clear prognosis as to the clinical evolution on diagnosis.

Our multidisciplinary research group consisting aims to respond to the different challenges presented by MS, broaden our knowledge of the disease, and to transfer this knowledge to the society.
 

Strategic objectives

- Be the reference group in the province of Girona for research and education in multiple sclerosis and other neurodegenerative diseases. 

- Have a national and international presence in the field of research into multiple sclerosis. 

- Consolidate clinical research in multiple sclerosis. - Initiate and consolidate basic research into multiple sclerosis. 

- Promote and lead research into new treatments for multiple sclerosis.

- Initiate clinical research into other neurodegenerative diseases (Parkinson's disease).

- Consolidate clinical research into hereditary ataxia.

- Establish research collaboration with other national and international groups working on multiple sclerosis.

- Promote research into multiple sclerosis in nursing and neuropsychology.

- Promote training and education in multiple sclerosis for healthcare professionals, specialists and affected patients and their family.

 

Main line of research

Priority clinical-healthcare lines: 

1. Study of neuropsychological disorders and cognitive rehabilitation in multiple sclerosis.

2. Study of the emotional impact, ability to cope, and adaptation to the diagnosis of multiple sclerosis.

3. Study of fatigue in multiple sclerosis.

4. Improve compliance with immunomodulatory treatment in multiple sclerosis.

5. Application of new brain MRI techniques as prognosis markers in multiple sclerosis.

6. Computer-based organisation of lesions detected by brain MRI in patients with multiple sclerosis.

 

Priority lines in basic research: 

1. Study of the gene expression in demyelinating diseases including multiple sclerosis.

2. Study of the molecular expression in multiple sclerosis as a model of chronic inflammatory disease.

3. Determination of biological prognosis factors in cerebrospinal fluid and serum for the evolution of multiple sclerosis (genetic factors, biochemical factors, environmental factors such as vitamin D, virus and others).

4. Determination of biological response factors (genetic and biochemical) to immunomodulatory treatments in multiple sclerosis.

5. Bank of DNA, CSF and serum samples of neuroimmunological diseases.

 

Main researcher

Lluís Ramió i Torrentà

 

Post-doctorate researchers 

Ester Quintana

Jordi Gich Fullà

René Robles

Jordi Tomàs

 

Medical researchers 

David Genís Batlle

Fabian Márquez

Brigitte Beltrán

Hector Perkal

 

Collaborators

Pepi López 

 

Technicians

Imma Gómez

Cristina Ridao

 

Nursing staff

Miguel Merchan Ruiz

Natalia González

Investigadors: 

Ester Quintana

Ester Quintana

Jordi Gich

Jordi Gich

Rebeca Menéndez

Rebeca Menéndez

René Robles

René Robles

Fabian Marquez

Fabian Marquez

Ana Quiles

Ana Quiles

David Genís

David Genís
Geoposicio: 

Project:  Estils de vida, característiques sociodemogràfiques i econòmiques, discapacitat, dolor, qualitat de vida, impulsivitat, suport social, i prevalença de factors de risc i de malalties cròniques de la població adulta de la província de Girona. (Girona, regió saludable).

Funding source: Generalitat de Catalunya i Diputació de Girona

Project reference: GO03-001848

Period, from:   2018    to: 2020

Principal investigator: Dr. Josep Puig / Dr. Rafel Ramos Blanes / Dr. Josep Garre Olmo

 

Project:  ReGiEM: Registre Gironí d'Esclerosi Múltiple

Funding source: Innobics – Institut Català de la Salut

Project reference:  INNOBICS-1961

Period, from: 2017       to: --

Principal investigator: Dr. René Robles Cedeño

 

Project:  EM-line Memory com a eina de rehbailitació cognitiva per a pacients que han patit un ictus

Funding source: Fundació Mutuam Conviure

Project reference:

Period, from: 2018       to: 2019

Principal investigator: Dr. Lluís Ramió i Torrentà

 

Project:  Imagenoma de l'Envelliment: Estudi observacional poblacional per al desenvolupament de biomarcadors d'imatge corporal integral basats en ressonància magnètica en individus de 50 anys d'edat o més i la seva relació amb factors de l'esfera biopsicosocial, cardiovascular, metabolòmica, lipidòmica, microbiòmica i altres factors associats a l'envelliment

Funding source: CDSA - Departament de Salut de la Generalitat de Catalunya

Project reference: SLT002/16/00250

Period, from: 2017       to: 2020

Principal investigator: Dr. Reinald Pamplona i Dr. Josep Puig

 

Project:  Red Española de Esclerosis Múltiple

Funding source: ISCA - Instituto de Salud Carlos III

Project reference: RD16/0015/0006

Period, from: 2017       to: 2021

Principal investigator: Dr. Lluís Ramió i Torrentà

 

Project:  Estudio de metiloma completo en células de sistema inmune de pacientes con esclerosis múltiple

Funding source: EFIS - Instituto de Salud Carlos III - Fondo de Investigación Sanitaria (FIS)

Project reference: PI16/01140

Period, from: 2016       to: 2019

Principal investigator: Dr. Lluís Ramió i Torrentà

 

Project:  New technologies applied to clinical practice for obtaining biomarkers of atrophy and lesions in magnetic resonance images of patients with multiple sclerosis (BiomarkEM.cat)

Funding source: FTV3 - Fundació La Marató de TV3

Project reference: 201425 30

Period, from: 2015       to: 2019

Principal investigator: Dr. Xavier Lladó Bardera

 

Project:  Determinación del patrón de miRNAs en líquido cefalorraquídeo y suero de pacientes con esclerosis múltiple. Asociación con otros biomarcadores

Funding source: Fundacion Salud 2000

Project reference: ---

Period, from: 2015       to: 2017

Principal investigator: Dr. Lluís Ramió i Torrentà

 

Project:  Herramientas de neuroimagen para mejorar el diagnosis y el seguimiento clínico de los pacientes con esclerosis múltiple (NICOLE)

Funding source: MECO - Ministerio de Economía y Competitividad

Project reference: TIN2014-55710-R

Period, from: 2015       to: 2017

Principal investigator: Dr. Xavier Lladó Bardera iDr. Joaquin Salvi Mas

 

Project:  Determinación en LCR de miRNAs implicados en las lesiones cerebrales activas de esclerosis múltiple

Funding source: Fundación Genzyme

Project reference: ---

Period, from: 2015       to: 2016

Principal investigator: Dr. Lluís Ramió i Torrentà

 

Project:  Estudio clínico y de ligamiento genético en una estirpe gitana afectada  por esclerosis múltiple.

Funding source: ISCA - Instituto de Salud Carlos III

Project reference: PI10/02649

Period, from: 2010       to: 2013

Principal investigator: Dr. Lluís Ramió i Torrentà

 

Project:  Papel de los miRNA en la esclerosis múltiple. estudio de miRNAs en líquido cefaloraquideo específicos para cada uno de los subtipos clínicos y de la respuesta a tratamiento.

Funding source: ISCA - Instituto de Salud Carlos III

Project reference: PI13/01782

Period, from: 2013       to: 2016

Principal investigator: Dr. Lluís Ramió i Torrentà

 

Project:  VitDEM. Vitamina D y Esclerosis Múltiple: diferencias bioquímicas y genéticas de los pacientes según niveles de vitamina D y su corelación clínico-radiológica

Funding source: Agrupació Ciències Mèdiques de Girona

Project reference: ---

Period, from: 2013       to: 2013

Principal investigator: Dr. René Robles

 

Project:  Avaluació de l'Atròfia en pacients amb Lesions d'Esclerosi Múltiple (AVALEM)

Funding source: Centre d'Esclerosi Múltiple de Catalunya

Project reference: X3_0700_E32_11_09_01

Period, from: 2011       to: 2013

Principal investigator: Dr. Xavier Lladó Bardera

 

Are you investigator?

English

If you research if you are interested in helping with any of our research groups, fill out this form. We will contact you as soon as possible. Thank you.

Send us your details

Read More