PURPOSE: Most patients with acute myeloid leukemia (AML) and genetic rearrangements involving the core binding factor (CBF) have favorable prognosis. In contrast, a minority of them still have a high risk of leukemia recurrence. This study investigated the adverse features of CBF AML that could justify investigational therapeutic approaches. PATIENTS AND METHODS: One hundred and fifty patients (median age 42 yr, range 16-69) with CBF AML (RUNX1-RUNX1T1 n = 74; CBFB-MYH11 n = 76) were prospectively enrolled into two consecutive CETLAM protocols at 19 Spanish institutions.
- Investigar aspectes biològics, clínics i epidemiològics de les malalties hematològiques
- Desenvolupar projectes de recerca translacional enfocats a trobar factors pronòstics o predictors de resposta a tractament
- Desenvolupar recerca clínica, potenciant la participació a assaigs clínics en malalties hematològiques i participant a grups cooperatius nacionals o internacionals.
Principals línies de recerca
Catalan
Red Transfonteriza de immunoterapias personalizadas para Linfomas No Hodgkin
Grup de Recerca Reconegut per la Generalitat de Catalunya
Finançat per: Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) (2014 SGR 21)
Durada: des de 2014 fins a 2016
Investigador responsable: David Gallardo
Minor Histocompatibility antigens as mediators of immune alloreactivity in human transplantation.
Finançat per: Fundació Marató TV3
Durada: des de 2013 fins a 2015
Investigador responsable: David Gallardo
Red de Cáncer. (RD12/0036/0029)
Finançat per: Instituto de Salud Carlos III
Durada: des de 2013 fins a 2015
Investigador responsable: Joan Gil Santano
Papel de los polimorfismos genéticos de CD38 Y CD31 en la leucemia linfática crónica.
Finançat per: Fundación Mutua Madrileña
Durada: des de 2011 fins a 2013
Investigador responsable: Josep Mª Roncero
Biobanco de aloTPH del GETH. Polimorfismos en antígenos menores de histocompatibilidad y genes moduladores de respuesta inmune como predictores de alorreactividad. (PI11/01690)
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The objectives of this study are to identify inequalities in mortality among census tracts of 11 Spanish cities in the period 1996-2003 and to analyse the relationship between these geographical inequalities and socioeconomic deprivation. It is a cross-sectional ecological study where the units of analysis are census tracts. We obtained an index of socioeconomic deprivation and estimated SMR by each census tract using hierarchical Bayesian models which take into account the spatial structure.
