SmartAge ESR project 9

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SmartAge ESR project 9
ANNOUNCEMENT REF.: SmartAge ESR project 9
BASES OF THE CALL.
POSITION ANNOUNCED.
 
The selective process is open for the coverage of 1 vacancy for a PhD student support at the
BIOMEDICAL RESEARCH INSTITUTE OF GIRONA DR. JOSEP TRUETA (IDIBGI) in the The Department of
Endocrinology (head of project: Prof. Dr. José Manuel Fernández-Real). IDIBGI offers a PhD position
for an Early-Stage Researcher (ESR) for the project: Impact of the gut microbiome on cognitive
function in middle-aged subjects. Effects of metformin. The position is part of the EU-funded
Innovative Training Network SmartAge (“Gut-brain-axis: Targets for improvement of cognition in the
elderly”)
 
Objective of the project:
 
To analyse the impact of age and metformin on gut-microbiome, and cognition. Different domains of
cognition will be explored: attention, memory and executive function (Stroop test, California verbal
learning test, Trail Making Test A and B) in association with metabolic variables and MRI scans
including diffusion tensor imaging (DTI). Blood samples will be collected to measure various markers
of microbial translocation/gut barrier function (bacterial endotoxins, CD14, LBP, ZO-1 and I-FABP),
inflammation (progranulin, CRP, Tnfá, IL-6, IL-1á, IL-1â) by qPCR and ELISA and to process for
metabolomics (e.g. SCFA). Diet and physical activity (recorded through accelerometers) will be
controlled. All these variables will be evaluated at baseline and one year thereafter in subjects >65-
75 years old after an intervention with metformin 850 mg b.i.d. Metformin is expected to impact on
cognitive improvement and the gut-microbiome as well as on the gut barrier function and
inflammaging.
 
The PhD student will join a research group with extensive experience in the study of the
pathophysiology of obesity, type 2 diabetes mellitus and their complications. The main traditional
lines of research are focused on innate immune system, inflammatory pathways, and metabolic
diseases. Furthermore, the group has done significant work evaluating the biology of human adipose
tissue and the role of the microbiome on the cognitive profiles of individuals with obesity and type 2
diabetes. Currently, the group is elucidating the complex interplay among the gut microbiome, the
metabolome (including microbial-host co-metabolites), brain microstructure, and cognitive
performance (memory, inhibitory control, etc.), and its modulation by obesity.
 
Requirements of the applicant:
 
We expect a Master ́s degree (accrediting between 60 and 120 ECTS credits at the official university
master's degree level or equivalent) in Health and/or Life Sciences (Systems Biology, Bioinformatics,
Psychology, Cognitive and Computational Neuroscience, Biomedicine, Biology) or Medicine.
Furthermore, the applicant should be able to perform team-oriented as well as independent work.
Desirable methodological skills include: excellent background in systems biology, neuroscience, and
metabolism, as well as experience in analysing large omics datasets and neuroimaging data. This will
include the use of a variety of R, Phyton, MATLAB, SPM, and FSL statistical packages (machine
learning algorithms, microbiome compositional data analysis, pattern recognition methods, brain
structural and connectivity analyses, etc.) to extract relevant biological information from individual
omics datasets (metabolomics, transcriptomics, and metagenomics) as well as from magnetic
resonance imaging data, and their integration.
 
Very good language skills in English are required. Given that the candidate will interact with local
patients, fluency in Spanish will be also considered.
 
Please note the eligibility criteria for researchers: Candidates must be in the first four years of his/her
research career, not have a doctoral degree, and not have resided in Spain for more than 12 months
in the 3 years immediately before the recruitment date.
 
We offer:
 
 Type of contract: Temporary
 Week: 40 hours per week
 Duration: 3 years
 Expected incorporation: March 2021
 The annual gross remuneration inherent to the vacancy subject to this call, will be determined
based on the experience provided and the skills of the candidates.
 
Selection process:
 
Interested candidates please send a motivation letter, a CV including publications (if available),
copies of university degrees and courses (including obtained grades), and the names and e-mail
addresses of two scientists who can provide references (all summarized in one pdf) to
 
Preferential treatment will be given to applications received before 30 November 2020.
 
For more information concerning the research project please contact Prof. Dr. José Manuel
Fernández-Real (email: jmfreal@idibgi.org).
 
Terms:
 
The recruitment will be carried out in accordance with the provisions of article 15 of Royal Legislative
Decree 1/1995, of March 24, which approves the revised text of the Workers' Statute Law, in
accordance with which has the art 2 of Royal Decree 2720/98, of December 18 (O. of January 8,
1999), Law 12/2001, of July 9 (O. of July 10) and concordant provisions.
 
The principle of equal treatment for men and women, in accordance with article 14 of the Spanish
Constitution, is taken into account, Directive 2006/54/EC of the European Parliament and the Council
and the provisions of Organic Law 3/2007, of March 22, and Law 17/2015, of July 21, for the effective
equality of men and women.
 
The universal accessibility of people with disabilities is considered in accordance with Legislative RD
1/2013, of November 29, which approves the Revised Text of the General Law on the rights of people
with disabilities and their inclusion social, making special reference to articles 35 and following where
the guarantees of the right to work are regulated.

Oferta de treball

Catalán

 

Si esteu interessats en aquesta oferta ompliu el formulari i enviu-nos el vostre CV
 

En aquesta pàgina es publiquen les ofertes de treball de l'Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta (IDIBGI).

Gràcies pel vostre interès.

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